Urine Proteome Analysis in Murine Nephrotoxic Serum Nephritis
نویسندگان
چکیده
منابع مشابه
Urine proteome analysis in murine nephrotoxic serum nephritis.
BACKGROUND Urine contains serum proteins filtered by the glomerulus or secreted by the renal tubules and proteins produced locally by the urinary tract. Proteomic analysis of urine holds the potential as a noninvasive means of studying or monitoring disease activity. In mice, large concentrations of albumin and lipocalins have complicated the ability to identify urinary biomarkers in disease mo...
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Studies have been carried out to determine the distribution of antigen capable of inducing the formation in rabbits of antibodies nephrotoxic for the rat. The results indicate that the antigen is present both in cortex and medulla of rat kidney. It can be extracted to a limited extent with saline. It is non-dialyzable and destroyed by boiling. The nephrotoxic serum antigen is also present in ra...
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Nephrotoxic anti-rat kidney sera were produced in rabbits by intraperitoneal injection of suspensions of blood-free rat kidney. The nephrotoxin of these sera could be removed by adsorption with saline suspensions of finely ground rat glomeruli, but not by adsorption with other portions of rat kidney or by adsorption with several other rat tissues. It was concluded that nephrotoxic sera of this ...
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Lipocalin-2 (Lcn-2) is involved in divergent processes such as acute kidney injury or bacterial host defence. Our study was designed to evaluate the functional role of Lcn-2 in nephrotoxic serum nephritis (NTS). Since Lcn-2 is expressed in tubular epithelial cells as well as in cells of innate immunity such as macrophages and polymorphonuclear neutrophils (PMN), we induced NTS in wild-type (WT)...
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ژورنال
عنوان ژورنال: American Journal of Nephrology
سال: 2009
ISSN: 1421-9670,0250-8095
DOI: 10.1159/000242430